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Paxilline inhibits BK channels by an almost exclusively closed-channel block mechanism
Paxilline, a tremorogenic fungal alkaloid, potently inhibits large conductance Ca(2+)- and voltage-activated K(+) (BK)-type channels, but little is known about the mechanism underlying this inhibition. Here we show that inhibition is inversely dependent on BK channel open probability (Po), and is fu...
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| Main Authors: | , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
The Rockefeller University Press
2014
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4210426/ https://ncbi.nlm.nih.gov/pubmed/25348413 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1085/jgp.201411259 |
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