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Closed-channel block of BK potassium channels by bbTBA requires partial activation

Blockade of large-conductance Ca(2+)-activated K(+) (BK) channels by the bulky quaternary ammonium compound, N-(4-[benzoyl]benzyl)-N,N,N-tributylammonium (bbTBA), exhibits features consistent with blockade of both closed and open states. Here, we examine block of closed BK channels by bbTBA and how...

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Detalhes bibliográficos
Main Authors: Tang, Qiong-Yao, Zeng, Xu-Hui, Lingle, Christopher J.
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2768800/
https://ncbi.nlm.nih.gov/pubmed/19858359
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1085/jgp.200910251
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