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Munc13-1 MUN domain and Munc18-1 cooperatively chaperone SNARE assembly through a tetrameric complex

Munc13-1 is a large multifunctional protein essential for synaptic vesicle fusion and neurotransmitter release. Its dysfunction has been linked to many neurological disorders. Evidence suggests that the MUN domain of Munc13-1 collaborates with Munc18-1 to initiate SNARE assembly, thereby priming ves...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Shu, Tong, Jin, Huaizhou, Rothman, James E., Zhang, Yongli
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2020
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6969487/
https://ncbi.nlm.nih.gov/pubmed/31888993
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1914361117
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