The effect of therapeutic drug monitoring of beta-lactam and fluoroquinolones on clinical outcome in critically ill patients: the DOLPHIN trial protocol of a multi-centre randomised controlled trial

BACKGROUND: Critically ill patients undergo extensive physiological alterations that will have impact on antibiotic pharmacokinetics. Up to 60% of intensive care unit (ICU) patients meet the pharmacodynamic targets of beta-lactam antibiotics, with only 30% in fluoroquinolones. Not reaching these tar...

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Detalhes bibliográficos
Publicado no:BMC Infect Dis
Main Authors: Abdulla, A., Ewoldt, T. M. J., Hunfeld, N. G. M., Muller, A. E., Rietdijk, W. J. R., Polinder, S., van Gelder, T., Endeman, H., Koch, B. C. P.
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2020
Assuntos:
Study Protocol
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6969462/
https://ncbi.nlm.nih.gov/pubmed/31952493
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12879-020-4781-x
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