Microenvironment-Dependent Gradient of CTL Exhaustion in the AE17sOVA Murine Mesothelioma Tumor Model

The immune system, and in particular, cytotoxic CD8(+) T cells (CTLs), plays a vital part in the prevention and elimination of tumors. In many patients, however, CTL-mediated tumor killing ultimately fails in the clearance of cancer cells resulting in disease progression, in large part due to the pr...

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Dades bibliogràfiques
Publicat a:Front Immunol
Autors principals: Hope, Jennifer L., Spantidea, Panagiota I., Kiernan, Caoimhe H., Stairiker, Christopher J., Rijsbergen, Laurine C., van Meurs, Marjan, Brouwers-Haspels, Inge, Mueller, Yvonne M., Nelson, Delia J., Bradley, Linda M., Aerts, Joachim G. J. V., Katsikis, Peter D.
Format: Artigo
Idioma:Inglês
Publicat: Frontiers Media S.A. 2020
Matèries:
Immunology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6968785/
https://ncbi.nlm.nih.gov/pubmed/31998326
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2019.03074
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