Rapid in vitro generation of bona fide exhausted CD8+ T cells is accompanied by Tcf7 promotor methylation

Exhaustion is a dysfunctional state of cytotoxic CD8+ T cells (CTL) observed in chronic infection and cancer. Current in vivo models of CTL exhaustion using chronic viral infections or cancer yield very few exhausted CTL, limiting the analysis that can be done on these cells. Establishing an in vitr...

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Detalhes bibliográficos
Publicado no:PLoS Pathog
Main Authors: Zhao, Manzhi, Kiernan, Caoimhe H., Stairiker, Christopher J., Hope, Jennifer L., Leon, Leticia G., van Meurs, Marjan, Brouwers-Haspels, Inge, Boers, Ruben, Boers, Joachim, Gribnau, Joost, van IJcken, Wilfred F. J., Bindels, Eric M., Hoogenboezem, Remco M., Erkeland, Stefan J., Mueller, Yvonne M., Katsikis, Peter D.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2020
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7340326/
https://ncbi.nlm.nih.gov/pubmed/32579593
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1008555
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