Rapid in vitro generation of bona fide exhausted CD8+ T cells is accompanied by Tcf7 promotor methylation

Exhaustion is a dysfunctional state of cytotoxic CD8+ T cells (CTL) observed in chronic infection and cancer. Current in vivo models of CTL exhaustion using chronic viral infections or cancer yield very few exhausted CTL, limiting the analysis that can be done on these cells. Establishing an in vitr...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:PLoS Pathog
Egile Nagusiak: Zhao, Manzhi, Kiernan, Caoimhe H., Stairiker, Christopher J., Hope, Jennifer L., Leon, Leticia G., van Meurs, Marjan, Brouwers-Haspels, Inge, Boers, Ruben, Boers, Joachim, Gribnau, Joost, van IJcken, Wilfred F. J., Bindels, Eric M., Hoogenboezem, Remco M., Erkeland, Stefan J., Mueller, Yvonne M., Katsikis, Peter D.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Public Library of Science 2020
Gaiak:
Research Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC7340326/
https://ncbi.nlm.nih.gov/pubmed/32579593
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1008555
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