USP37 Promotes Lung Cancer Cell Migration by Stabilizing Snail Protein via Deubiquitination

Snail is a prominent epithelial–mesenchymal transition (EMT) transcription factor and promotes metastasis. However, Snail protein is unstable and is quickly degraded through ubiquitination-mediated proteasome pathway. Deubiquitinases prevent Snail degradation by regulating the ubiquitination-mediate...

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Udgivet i:Front Genet
Main Authors: Cai, Jiali, Li, Mengying, Wang, Xiang, Li, Lei, Li, Qi, Hou, Zhaoyuan, Jia, Hao, Liu, Shiyuan
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2020
Fag:
Genetics
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6967296/
https://ncbi.nlm.nih.gov/pubmed/31998374
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fgene.2019.01324
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