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IL-24 Inhibits Lung Cancer Growth by Suppressing GLI1 and Inducing DNA Damage

Aberrant expression of GLI1 is responsible for aggressive tumor behavior and survival due to its effects on the DNA damage response (DDR). We investigated whether interleukin (IL)-24, a tumor suppressor, inhibits GLI1 and the associated DDR pathway in human NSCLCs. IL-24 treatment reduces mRNA and p...

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Detalhes bibliográficos
Publicado no:Cancers (Basel)
Main Authors: Panneerselvam, Janani, Srivastava, Akhil, Mehta, Meghna, Chen, Allshine, Zhao, Yan D., Munshi, Anupama, Ramesh, Rajagopal
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6966580/
https://ncbi.nlm.nih.gov/pubmed/31783569
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cancers11121879
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