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p53-Mediated Tumor Suppression: DNA-Damage Response and Alternative Mechanisms

The tumor suppressor p53 regulates different cellular pathways involved in cell survival, DNA repair, apoptosis, and senescence. However, according to an increasing number of studies, the p53-mediated canonical DNA damage response is dispensable for tumor suppression. p53 is involved in mechanisms r...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Cancers (Basel)
Hauptverfasser: Pitolli, Consuelo, Wang, Ying, Candi, Eleonora, Shi, Yufang, Melino, Gerry, Amelio, Ivano
Format: Artigo
Sprache:Inglês
Veröffentlicht: MDPI 2019
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6966539/
https://ncbi.nlm.nih.gov/pubmed/31835405
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cancers11121983
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