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Context is everything: extrinsic signalling and gain-of-function p53 mutants

The TP53 genomic locus is a target of mutational events in at least half of cancers. Despite several decades of study, a full consensus on the relevance of the acquisition of p53 gain-of-function missense mutants has not been reached. Depending on cancer type, type of mutations and other unidentifie...

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Bibliografiska uppgifter
I publikationen:Cell Death Discov
Huvudupphovsmän: Amelio, Ivano, Melino, Gerry
Materialtyp: Artigo
Språk:Inglês
Publicerad: Nature Publishing Group UK 2020
Ämnen:
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC7090043/
https://ncbi.nlm.nih.gov/pubmed/32218993
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41420-020-0251-x
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