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Glucose Depletion Enhances the Stem Cell Phenotype and Gemcitabine Resistance of Cholangiocarcinoma Organoids through AKT Phosphorylation and Reactive Oxygen Species

Cancer cells are strongly dependent on the glycolytic pathway for generation of energy even under aerobic condition through a phenomenon known as the Warburg effect. Rapid proliferation of cancer cells is often accompanied by high glucose consumption and abnormal angiogenesis, which may lead to gluc...

詳細記述

保存先:
書誌詳細
出版年:Cancers (Basel)
主要な著者: Yoshikawa, Nao, Saito, Yoshimasa, Manabe, Hiroki, Nakaoka, Toshiaki, Uchida, Ryoei, Furukawa, Ryo, Muramatsu, Toshihide, Sugiyama, Yuko, Kimura, Masaki, Saito, Hidetsugu
フォーマット: Artigo
言語:Inglês
出版事項: MDPI 2019
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC6966500/
https://ncbi.nlm.nih.gov/pubmed/31835877
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cancers11121993
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