Epigenetic silencing of Lgr5 induces senescence of intestinal epithelial organoids during the process of aging

To understand the molecular features underlying stem cell aging, we established intestinal epithelial organoids derived from both young and aged mice and investigated alterations in their senescence and epigenetic status. Senescence-related changes including accumulation of senescence-associated β-g...

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Detalhes bibliográficos
Publicado no:NPJ Aging Mech Dis
Main Authors: Uchida, Ryoei, Saito, Yoshimasa, Nogami, Kazuki, Kajiyama, Yohei, Suzuki, Yukana, Kawase, Yasuhiro, Nakaoka, Toshiaki, Muramatsu, Toshihide, Kimura, Masaki, Saito, Hidetsugu
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6279747/
https://ncbi.nlm.nih.gov/pubmed/30534415
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41514-018-0031-5
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