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Epigenetic silencing of Lgr5 induces senescence of intestinal epithelial organoids during the process of aging
To understand the molecular features underlying stem cell aging, we established intestinal epithelial organoids derived from both young and aged mice and investigated alterations in their senescence and epigenetic status. Senescence-related changes including accumulation of senescence-associated β-g...
Αποθηκεύτηκε σε:
| Τόπος έκδοσης: | NPJ Aging Mech Dis |
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| Κύριοι συγγραφείς: | , , , , , , , , , |
| Μορφή: | Artigo |
| Γλώσσα: | Inglês |
| Έκδοση: |
Nature Publishing Group UK
2018
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| Θέματα: | |
| Διαθέσιμο Online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6279747/ https://ncbi.nlm.nih.gov/pubmed/30534415 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41514-018-0031-5 |
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