Surface Plasmon Resonance as a Tool for Ligand Binding Investigation of Engineered GPR17 Receptor, a G Protein Coupled Receptor Involved in Myelination

The aim of this study was to investigate the potential of surface plasmon resonance (SPR) spectroscopy for the measurement of real-time ligand-binding affinities and kinetic parameters for GPR17, a G protein-coupled receptor (GPCR) of major interest in medicinal chemistry as potential target in demy...

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Detalhes bibliográficos
Publicado no:Front Chem
Main Authors: Capelli, Davide, Parravicini, Chiara, Pochetti, Giorgio, Montanari, Roberta, Temporini, Caterina, Rabuffetti, Marco, Trincavelli, Maria Letizia, Daniele, Simona, Fumagalli, Marta, Saporiti, Simona, Bonfanti, Elisabetta, Abbracchio, Maria P., Eberini, Ivano, Ceruti, Stefania, Calleri, Enrica, Capaldi, Stefano
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2020
Assuntos:
Chemistry
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6966494/
https://ncbi.nlm.nih.gov/pubmed/31998697
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fchem.2019.00910
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