Targeting FAT1 Inhibits Carcinogenesis, Induces Oxidative Stress and Enhances Cisplatin Sensitivity through Deregulation of LRP5/WNT2/GSS Signaling Axis in Oral Squamous Cell Carcinoma

FAT atypical cadherin 1 (FAT1) regulates cell-cell adhesion and extracellular matrix architecture, while acting as tumor suppressor or oncogene, context-dependently. Despite implication of FAT1 in several malignancies, its role in oral squamous cell carcinoma (OSCC) remains unclear. Herein, we docum...

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Detalhes bibliográficos
Publicado no:Cancers (Basel)
Main Authors: Hsu, Tung-Nien, Huang, Chih-Ming, Huang, Chin-Sheng, Huang, Mao-Suan, Yeh, Chi-Tai, Chao, Tsu-Yi, Bamodu, Oluwaseun Adebayo
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6966489/
https://ncbi.nlm.nih.gov/pubmed/31783581
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cancers11121883
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