Cadherin 11 Inhibition Downregulates β-catenin, Deactivates the Canonical WNT Signalling Pathway and Suppresses the Cancer Stem Cell-Like Phenotype of Triple Negative Breast Cancer

Background: Cancer stem cells (CSCs) promote tumor progression and distant metastasis in breast cancer. Cadherin 11 (CDH11) is overexpressed in invasive breast cancer cells and implicated in distant bone metastases in several cancers. The WNT signalling pathway regulates CSC activity. Growing eviden...

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Veröffentlicht in:J Clin Med
Hauptverfasser: Satriyo, Pamungkas Bagus, Bamodu, Oluwaseun Adebayo, Chen, Jia-Hong, Aryandono, Teguh, Haryana, Sofia Mubarika, Yeh, Chi-Tai, Chao, Tsu-Yi
Format: Artigo
Sprache:Inglês
Veröffentlicht: MDPI 2019
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6407101/
https://ncbi.nlm.nih.gov/pubmed/30691241
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/jcm8020148
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