A Novel Multi-Target Small Molecule, LCC-09, Inhibits Stemness and Therapy-Resistant Phenotypes of Glioblastoma Cells by Increasing miR-34a and Deregulating the DRD4/Akt/mTOR Signaling Axis

The management of glioblastomas (GBMs) is challenged by the development of therapeutic resistance and early disease recurrence, despite multi-modal therapy. This may be attributed to the presence of glioma stem cells (GSCs) which are known to survive radio- and chemotherapy, by circumventing death s...

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Dettagli Bibliografici
Pubblicato in:Cancers (Basel)
Autori principali: Wen, Ya-Ting, Wu, Alexander TH, Bamodu, Oluwaseun Adebayo, Wei, Li, Lin, Chien-Min, Yen, Yun, Chao, Tsu-Yi, Mukhopadhyay, Debabrata, Hsiao, Michael, Huang, Hsu-Shan
Natura: Artigo
Lingua:Inglês
Pubblicazione: MDPI 2019
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6826618/
https://ncbi.nlm.nih.gov/pubmed/31561595
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cancers11101442
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