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Synchronous inhibition of mTOR and VEGF/NRP1 axis impedes tumor growth and metastasis in renal cancer

Clear cell renal cell carcinoma (ccRCC) is known for its highly vascular phenotype which is associated with elevated expression of vascular endothelial growth factor A (VEGF), also known as vascular permeability factor (VPF). Accordingly, VEGF has been an attractive target for antiangiogenic therapi...

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Detalhes bibliográficos
Publicado no:NPJ Precis Oncol
Main Authors: Pal, Krishnendu, Madamsetty, Vijay Sagar, Dutta, Shamit Kumar, Wang, Enfeng, Angom, Ramcharan Singh, Mukhopadhyay, Debabrata
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6895165/
https://ncbi.nlm.nih.gov/pubmed/31840081
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41698-019-0105-2
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