In Chronic Lymphocytic Leukemia the JAK2/STAT3 Pathway Is Constitutively Activated and Its Inhibition Leads to CLL Cell Death Unaffected by the Protective Bone Marrow Microenvironment

The bone marrow microenvironment promotes proliferation and drug resistance in chronic lymphocytic leukemia (CLL). Although ibrutinib is active in CLL, it is rarely able to clear leukemic cells protected by bone marrow mesenchymal stromal cells (BMSCs) within the marrow niche. We investigated the mo...

Full description

Saved in:
Bibliographic Details
Published in:Cancers (Basel)
Main Authors: Severin, Filippo, Frezzato, Federica, Visentin, Andrea, Martini, Veronica, Trimarco, Valentina, Carraro, Samuela, Tibaldi, Elena, Brunati, Anna Maria, Piazza, Francesco, Semenzato, Gianpietro, Facco, Monica, Trentin, Livio
Format: Artigo
Language:Inglês
Published: MDPI 2019
Subjects:
Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6966457/
https://ncbi.nlm.nih.gov/pubmed/31817171
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cancers11121939
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items