In Chronic Lymphocytic Leukemia the JAK2/STAT3 Pathway Is Constitutively Activated and Its Inhibition Leads to CLL Cell Death Unaffected by the Protective Bone Marrow Microenvironment

The bone marrow microenvironment promotes proliferation and drug resistance in chronic lymphocytic leukemia (CLL). Although ibrutinib is active in CLL, it is rarely able to clear leukemic cells protected by bone marrow mesenchymal stromal cells (BMSCs) within the marrow niche. We investigated the mo...

Descrizione completa

Salvato in:
Dettagli Bibliografici
Pubblicato in:Cancers (Basel)
Autori principali: Severin, Filippo, Frezzato, Federica, Visentin, Andrea, Martini, Veronica, Trimarco, Valentina, Carraro, Samuela, Tibaldi, Elena, Brunati, Anna Maria, Piazza, Francesco, Semenzato, Gianpietro, Facco, Monica, Trentin, Livio
Natura: Artigo
Lingua:Inglês
Pubblicazione: MDPI 2019
Soggetti:
Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6966457/
https://ncbi.nlm.nih.gov/pubmed/31817171
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cancers11121939
Tags: Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne! !

Documenti analoghi