In Chronic Lymphocytic Leukemia the JAK2/STAT3 Pathway Is Constitutively Activated and Its Inhibition Leads to CLL Cell Death Unaffected by the Protective Bone Marrow Microenvironment

The bone marrow microenvironment promotes proliferation and drug resistance in chronic lymphocytic leukemia (CLL). Although ibrutinib is active in CLL, it is rarely able to clear leukemic cells protected by bone marrow mesenchymal stromal cells (BMSCs) within the marrow niche. We investigated the mo...

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Kaydedildi:
Detaylı Bibliyografya
Yayımlandı:Cancers (Basel)
Asıl Yazarlar: Severin, Filippo, Frezzato, Federica, Visentin, Andrea, Martini, Veronica, Trimarco, Valentina, Carraro, Samuela, Tibaldi, Elena, Brunati, Anna Maria, Piazza, Francesco, Semenzato, Gianpietro, Facco, Monica, Trentin, Livio
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: MDPI 2019
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6966457/
https://ncbi.nlm.nih.gov/pubmed/31817171
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cancers11121939
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