In Chronic Lymphocytic Leukemia the JAK2/STAT3 Pathway Is Constitutively Activated and Its Inhibition Leads to CLL Cell Death Unaffected by the Protective Bone Marrow Microenvironment

The bone marrow microenvironment promotes proliferation and drug resistance in chronic lymphocytic leukemia (CLL). Although ibrutinib is active in CLL, it is rarely able to clear leukemic cells protected by bone marrow mesenchymal stromal cells (BMSCs) within the marrow niche. We investigated the mo...

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發表在:Cancers (Basel)
Main Authors: Severin, Filippo, Frezzato, Federica, Visentin, Andrea, Martini, Veronica, Trimarco, Valentina, Carraro, Samuela, Tibaldi, Elena, Brunati, Anna Maria, Piazza, Francesco, Semenzato, Gianpietro, Facco, Monica, Trentin, Livio
格式: Artigo
語言:Inglês
出版: MDPI 2019
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Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC6966457/
https://ncbi.nlm.nih.gov/pubmed/31817171
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cancers11121939
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