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Lack of mutant huntingtin in cortical efferents improves behavioral inflexibility and corticostriatal dynamics in Huntington’s disease mice

Abnormal communication between cerebral cortex and striatum plays a major role in the motor symptoms of Huntington’s disease (HD), a neurodegenerative disorder caused by a mutation of the huntingtin gene (mHTT). Because cortex is the main driver of striatal processing, we recorded local field potent...

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Опубликовано в: :J Neurophysiol
Главные авторы: Estrada-Sánchez, Ana María, Blake, Courtney L., Barton, Scott J., Howe, Andrew G., Rebec, George V.
Формат: Artigo
Язык:Inglês
Опубликовано: American Physiological Society 2019
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC6966319/
https://ncbi.nlm.nih.gov/pubmed/31693428
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/jn.00777.2018
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