Superoxide induced inhibition of death receptor signaling is mediated via induced expression of apoptosis inhibitory protein cFLIP

The death inhibitory proteins, cFLIP and Bcl-2, canonically act at different steps to regulate receptor-mediated apoptosis in cancer cells. Here we report that pharmacological or genetic means to effect an increase in intracellular superoxide result in cFLIP upregulation. Interestingly, Bcl-2 overex...

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Détails bibliographiques
Publié dans:Redox Biol
Auteurs principaux: Hirpara, Jayshree L., Subramaniam, Kothandharaman, Bellot, Gregory, Qu, Jianhua, Seah, Serena, Loh, Thomas, Tucker-Kellogg, Lisa, Clement, Marie-Veronique, Pervaiz, Shazib
Format: Artigo
Langue:Inglês
Publié: Elsevier 2019
Sujets:
Research Paper
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6965745/
https://ncbi.nlm.nih.gov/pubmed/31954371
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.redox.2019.101403
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