Overexpression of Bcl-2 induces STAT-3 activation via an increase in mitochondrial superoxide

We recently reported a novel interaction between Bcl-2 and Rac1 and linked that to the ability of Bcl-2 to induce a pro-oxidant state in cancer cells. To gain further insight into the functional relevance of this interaction, we utilized computer simulation based on the protein pathway dynamic netwo...

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Pubblicato in:Oncotarget
Autori principali: Kang, Jia, Chong, Stephen Jun Fei, Ooi, Vignette Zi Qi, Vali, Shireen, Kumar, Ansu, Kapoor, Shweta, Abbasi, Taher, Hirpara, Jayshree L., Loh, Thomas, Goh, Boon Cher, Pervaiz, Shazib
Natura: Artigo
Lingua:Inglês
Pubblicazione: Impact Journals LLC 2015
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Research paper: Autophagy and Cell Death
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4741445/
https://ncbi.nlm.nih.gov/pubmed/26430964
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