Enhanced STAT3 phosphorylation and PD-L1 expression in myeloid dendritic cells indicate impaired IL-27Ralpha signaling in type 1 diabetes

Interleukin 27 (IL-27), a member of the IL-12 family, is important for T cell differentiation; however, little is known about its effect on dendritic cells (DCs). IL-27 can activate multiple signaling cascades, including the JAK/STAT pathway, and depending on the setting it can both promote and anta...

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Published in:Sci Rep
Main Authors: Parackova, Z., Vrabcova, P., Zentsova, I., Kayserova, J., Richtrova, I., Sojka, L., Stechova, K., Sumnik, Z., Sediva, A.
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2020
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6965661/
https://ncbi.nlm.nih.gov/pubmed/31949260
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-57507-8
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