Synovial T cell hyporesponsiveness to myeloid dendritic cells is reversed by preventing PD-1/PD-L1 interactions

INTRODUCTION: The aim of this study was to investigate PD-1/PD-L1 involvement in the hyporesponsiveness of rheumatoid arthritis (RA) synovial fluid (SF) CD4 T cells upon stimulation by thymic stromal lymphopoietin (TSLP)–primed CD1c myeloid dendritic cells (mDCs). METHODS: Expression of PD-1 on naïv...

Full description

Saved in:
Bibliographic Details
Published in:Arthritis Res Ther
Main Authors: Moret, Frederique M, van der Wurff-Jacobs, Kim MG, Bijlsma, Johannes WJ, Lafeber, Floris PJG, van Roon, Joel AG
Format: Artigo
Language:Inglês
Published: BioMed Central 2014
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4266919/
https://ncbi.nlm.nih.gov/pubmed/25433812
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13075-014-0497-x
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items