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Differential direct effects of cyclo-oxygenase-1/2 inhibition on proteoglycan turnover of human osteoarthritic cartilage: an in vitro study

Treatment of osteoarthritis (OA) with nonsteroidal anti-inflammatory drugs (NSAIDs) diminishes inflammation along with mediators of cartilage destruction. However, NSAIDs may exert adverse direct effects on cartilage, particularly if treatment is prolonged. We therefore compared the direct effects o...

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Hlavní autoři: Mastbergen, Simon C, Jansen, Nathalie WD, Bijlsma, Johannes WJ, Lafeber, Floris PJG
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2006
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1526565/
https://ncbi.nlm.nih.gov/pubmed/16356188
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/ar1846
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