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Lentiviral Vector Production Titer Is Not Limited in HEK293T by Induced Intracellular Innate Immunity
Most gene therapy lentiviral vector (LV) production platforms employ HEK293T cells expressing the oncogenic SV40 large T-antigen (TAg) that is thought to promote plasmid-mediated gene expression. Studies on other viral oncogenes suggest that TAg may also inhibit the intracellular autonomous innate i...
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| Опубликовано в: : | Mol Ther Methods Clin Dev |
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| Главные авторы: | , , , , , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
American Society of Gene & Cell Therapy
2019
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6965512/ https://ncbi.nlm.nih.gov/pubmed/31970199 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.omtm.2019.11.021 |
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