Lentiviral Vector Production Titer Is Not Limited in HEK293T by Induced Intracellular Innate Immunity

Most gene therapy lentiviral vector (LV) production platforms employ HEK293T cells expressing the oncogenic SV40 large T-antigen (TAg) that is thought to promote plasmid-mediated gene expression. Studies on other viral oncogenes suggest that TAg may also inhibit the intracellular autonomous innate i...

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Bibliographic Details
Published in:Mol Ther Methods Clin Dev
Main Authors: Ferreira, Carolina B., Sumner, Rebecca P., Rodriguez-Plata, Maria T., Rasaiyaah, Jane, Milne, Richard S., Thrasher, Adrian J., Qasim, Waseem, Towers, Greg J.
Format: Artigo
Language:Inglês
Published: American Society of Gene & Cell Therapy 2019
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6965512/
https://ncbi.nlm.nih.gov/pubmed/31970199
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.omtm.2019.11.021
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