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To Be or Not To Be…Toxic—Is RNA Association With TDP-43 Complexes Deleterious or Protective in Neurodegeneration?

TAR DNA binding protein (TDP-43) is a nucleic acid binding protein associated with insoluble cytoplasmic aggregates in several neurodegenerative disorders, including 97% of the ALS cases. In healthy individuals, TDP-43 is primarily localized to the nucleus; it can shuttle between the nucleus and the...

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Dades bibliogràfiques
Publicat a:Front Mol Biosci
Autors principals: Loganathan, Suvithanandhini, Lehmkuhl, Erik M., Eck, Randall J., Zarnescu, Daniela C.
Format: Artigo
Idioma:Inglês
Publicat: Frontiers Media S.A. 2020
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6965497/
https://ncbi.nlm.nih.gov/pubmed/31998750
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fmolb.2019.00154
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