A spontaneous mitonuclear epistasis converging on Rieske Fe-S protein exacerbates complex III deficiency in mice

We previously observed an unexpected fivefold (35 vs. 200 days) difference in the survival of respiratory chain complex III (CIII) deficient Bcs1l(p.S78G) mice between two congenic backgrounds. Here, we identify a spontaneous homoplasmic mtDNA variant (m.G14904A, mt-Cyb(p.D254N)), affecting the CIII...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Purhonen, Janne, Grigorjev, Vladislav, Ekiert, Robert, Aho, Noora, Rajendran, Jayasimman, Pietras, Rafał, Truvé, Katarina, Wikström, Mårten, Sharma, Vivek, Osyczka, Artur, Fellman, Vineta, Kallijärvi, Jukka
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6965120/
https://ncbi.nlm.nih.gov/pubmed/31949167
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-14201-2
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