Multiple Dynamical Mechanisms of Phase-2 Early Afterdepolarizations in a Human Ventricular Myocyte Model: Involvement of Spontaneous SR Ca(2+) Release

Early afterdepolarization (EAD) is known to cause lethal ventricular arrhythmias in long QT syndrome (LQTS). In this study, dynamical mechanisms of EAD formation in human ventricular myocytes (HVMs) were investigated using the mathematical model developed by ten Tusscher and Panfilov (Am J Physiol H...

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Detalles Bibliográficos
Publicado en:Front Physiol
Main Authors: Kurata, Yasutaka, Tsumoto, Kunichika, Hayashi, Kenshi, Hisatome, Ichiro, Kuda, Yuhichi, Tanida, Mamoru
Formato: Artigo
Idioma:Inglês
Publicado: Frontiers Media S.A. 2020
Assuntos:
Physiology
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6965073/
https://ncbi.nlm.nih.gov/pubmed/31998140
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphys.2019.01545
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