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Sonic Hedgehog upregulation does not enhance the survival and engraftment of stem cell-derived cardiomyocytes in infarcted hearts

The engraftment of human stem cell-derived cardiomyocytes (hSC-CMs) is a promising treatment for remuscularizing the heart wall post-infarction, but it is plagued by low survival of transplanted cells. We hypothesize that this low survival rate is due to continued ischemia within the infarct, and th...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Weyers, Jill J., Gunaje, Jagadambika J., Van Biber, Benjamin, Martinson, Amy, Reinecke, Hans, Mahoney, William M., Schwartz, Stephen M., Cox, Timothy C., Murry, Charles E.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6964843/
https://ncbi.nlm.nih.gov/pubmed/31945113
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0227780
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