Regulator of G-Protein Signaling – 5 (RGS5) Is a Novel Repressor of Hedgehog Signaling

Hedgehog (Hh) signaling plays fundamental roles in morphogenesis, tissue repair, and human disease. Initiation of Hh signaling is controlled by the interaction of two multipass membrane proteins, patched (Ptc) and smoothened (Smo). Recent studies identify Smo as a G-protein coupled receptor (GPCR)-l...

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Bibliografiske detaljer
Main Authors: Mahoney, William M., Gunaje, Jagadambika, Daum, Guenter, Dong, Xiu Rong, Majesky, Mark W.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2013
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3630190/
https://ncbi.nlm.nih.gov/pubmed/23637832
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0061421
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