Recurrent Genetic Abnormalities in Human Pluripotent Stem Cells: Definition and Routine Detection in Culture Supernatant by Targeted Droplet Digital PCR

Genomic integrity of human pluripotent stem cells (hPSCs) is essential for research and clinical applications. However, genetic abnormalities can accumulate during hPSC generation and routine culture and following gene editing. Their occurrence should be regularly monitored, but the current assays t...

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Detalhes bibliográficos
Publicado no:Stem Cell Reports
Main Authors: Assou, Said, Girault, Nicolas, Plinet, Mathilde, Bouckenheimer, Julien, Sansac, Caroline, Combe, Marion, Mianné, Joffrey, Bourguignon, Chloé, Fieldes, Mathieu, Ahmed, Engi, Commes, Thérèse, Boureux, Anthony, Lemaître, Jean-Marc, De Vos, John
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2020
Assuntos:
Report
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6962701/
https://ncbi.nlm.nih.gov/pubmed/31902703
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stemcr.2019.12.004
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