Irp2 regulates insulin production through iron-mediated Cdkal1-catalyzed tRNA modification

Regulation of cellular iron homeostasis is crucial as both iron excess and deficiency cause hematological and neurodegenerative diseases. Here we show that mice lacking iron-regulatory protein 2 (Irp2), a regulator of cellular iron homeostasis, develop diabetes. Irp2 post-transcriptionally regulates...

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Publicado no:Nat Commun
Main Authors: Santos, Maria C. Ferreira dos, Anderson, Cole P., Neschen, Susanne, Zumbrennen-Bullough, Kimberly B., Romney, Steven J., Kahle-Stephan, Melanie, Rathkolb, Birgit, Gailus-Durner, Valerie, Fuchs, Helmut, Wolf, Eckhard, Rozman, Jan, de Angelis, Martin Hrabe, Cai, Weiling Maggie, Rajan, Malini, Hu, Jennifer, Dedon, Peter C., Leibold, Elizabeth A.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6962211/
https://ncbi.nlm.nih.gov/pubmed/31941883
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-14004-5
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