Multivalent Interactions with gp120 Are Required for the Anti-HIV Activity of Cyanovirin

Cyanovirin-N (CV-N) is a cyanobacterial lectin that binds to specific oligomannoses on the surface ofgp120, resulting in nanomolar antiviral activity against HIV. In its monomeric form, CV-N contains two functional carbohydrate-binding domains, A and B. When refolded at high concentration, the prote...

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Detalles Bibliográficos
Publicado en:Biopolymers
Main Authors: Liu, Yinan, Carroll, Jacob R., Holt, Lindsey A., McMahon, James, Giomarelli, Barbara, Ghirlanda, Giovanna
Formato: Artigo
Idioma:Inglês
Publicado: 2009
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6961781/
https://ncbi.nlm.nih.gov/pubmed/19235857
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/bip.21173
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