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Interaction between somatic mutations and germline variants contributes to clinical heterogeneity in cancer

Deciphering principles of inter-tumoral heterogeneity is crucial for refinement of precision oncology. We have recently demonstrated that ‘oncogenic cooperation‘ between somatic mutations and regulatory germline variants can serve as a major cause for inter-tumoral heterogeneity, suggesting the requ...

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Publicat a:Mol Cell Oncol
Autors principals: Musa, Julian, Grünewald, Thomas G. P.
Format: Artigo
Idioma:Inglês
Publicat: Taylor & Francis 2019
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6961672/
https://ncbi.nlm.nih.gov/pubmed/31993496
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/23723556.2019.1682924
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