A genome-wide long noncoding RNA CRISPRi screen identifies PRANCR as a novel regulator of epidermal homeostasis

Genome-wide association studies indicate that many disease susceptibility regions reside in non-protein-coding regions of the genome. Long noncoding RNAs (lncRNAs) are a major component of the noncoding genome, but their biological impacts are not fully understood. Here, we performed a CRISPR interf...

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Dettagli Bibliografici
Pubblicato in:Genome Res
Autori principali: Cai, Pengfei, Otten, Auke B.C., Cheng, Binbin, Ishii, Mitsuhiro A., Zhang, Wen, Huang, Beibei, Qu, Kun, Sun, Bryan K.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Cold Spring Harbor Laboratory Press 2020
Soggetti:
Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6961571/
https://ncbi.nlm.nih.gov/pubmed/31804951
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gr.251561.119
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