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High content phenotypic screening identifies serotonin receptor modulators with selective activity upon breast cancer cell cycle and cytokine signaling pathways

Heterogeneity in disease mechanisms between genetically distinct patients contributes to high attrition rates in late stage clinical drug development. New personalized medicine strategies aim to identify predictive biomarkers which stratify patients most likely to respond to a particular therapy. Ho...

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Detalhes bibliográficos
Publicado no:Bioorg Med Chem
Main Authors: Warchal, Scott J., Dawson, John C., Shepherd, Emelie, Munro, Alison F., Hughes, Rebecca E., Makda, Ashraff, Carragher, Neil O.
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier Science 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6961118/
https://ncbi.nlm.nih.gov/pubmed/31757681
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2019.115209
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