High-Content Phenotypic Profiling in Esophageal Adenocarcinoma Identifies Selectively Active Pharmacological Classes of Drugs for Repurposing and Chemical Starting Points for Novel Drug Discovery

Esophageal adenocarcinoma (EAC) is a highly heterogeneous disease, dominated by large-scale genomic rearrangements and copy number alterations. Such characteristics have hampered conventional target-directed drug discovery and personalized medicine strategies, contributing to poor outcomes for patie...

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Detalhes bibliográficos
Publicado no:SLAS Discov
Main Authors: Hughes, Rebecca E., Elliott, Richard J. R., Munro, Alison F., Makda, Ashraff, O’Neill, J. Robert, Hupp, Ted, Carragher, Neil O.
Formato: Artigo
Idioma:Inglês
Publicado em: SAGE Publications 2020
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7372582/
https://ncbi.nlm.nih.gov/pubmed/32441181
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/2472555220917115
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