PLK4 deubiquitination by Spata2‐CYLD suppresses NEK7‐mediated NLRP3 inflammasome activation at the centrosome

The innate immune sensor NLRP3 assembles an inflammasome complex with NEK7 and ASC to activate caspase‐1 and drive the maturation of proinflammatory cytokines IL‐1β and IL‐18. NLRP3 inflammasome activity must be tightly controlled, as its over‐activation is involved in the pathogenesis of inflammato...

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Опубликовано в: :EMBO J
Главные авторы: Yang, Xiao‐Dong, Li, Wenguo, Zhang, Shuangyan, Wu, Dandan, Jiang, Xiaoli, Tan, Rong, Niu, Xiaoyin, Wang, Qijun, Wu, Xuefeng, Liu, Zhiduo, Chen, Lin‐Feng, Qin, Jun, Su, Bing
Формат: Artigo
Язык:Inglês
Опубликовано: John Wiley and Sons Inc. 2019
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Articles
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC6960439/
https://ncbi.nlm.nih.gov/pubmed/31762063
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.2019102201
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