CpG Frequency in the 5′ Third of the env Gene Determines Sensitivity of Primary HIV-1 Strains to the Zinc-Finger Antiviral Protein

CpG dinucleotide suppression has been reported to allow HIV-1 to evade inhibition by the zinc-finger antiviral protein (ZAP). Here, we show that primate lentiviruses display marked differences in CpG frequencies across their genome, ranging from 0.44% in simian immunodeficiency virus SIVwrc from Wes...

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Detalhes bibliográficos
Publicado no:mBio
Main Authors: Kmiec, Dorota, Nchioua, Rayhane, Sherrill-Mix, Scott, Stürzel, Christina M., Heusinger, Elena, Braun, Elisabeth, Gondim, Marcos V. P., Hotter, Dominik, Sparrer, Konstantin M. J., Hahn, Beatrice H., Sauter, Daniel, Kirchhoff, Frank
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2020
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6960287/
https://ncbi.nlm.nih.gov/pubmed/31937644
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/mBio.02903-19
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