Activation of Mitochondrial Unfolded Protein Response in SHSY5Y Expressing APP Cells and APP/PS1 Mice

Alzheimer disease (AD) is the most common form of dementia. Amyloid β-peptide (Aβ) deposition is a major neuropathologic feature of AD. When unfolded or misfolded proteins accumulate in mitochondria, the unfolded protein responses (UPRmt) is initiated. Numerous lines of evidence show that AD pathoge...

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Pubblicato in:Front Cell Neurosci
Autori principali: Shen, Yang, Ding, Mao, Xie, Zhaohong, Liu, Xiangtian, Yang, Hui, Jin, Suqin, Xu, Shunliang, Zhu, Zhengyu, Wang, Yun, Wang, Dewei, Xu, Linlin, Zhou, Xiaoyan, Wang, Ping, Bi, Jianzhong
Natura: Artigo
Lingua:Inglês
Pubblicazione: Frontiers Media S.A. 2020
Soggetti:
Cellular Neuroscience
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6960128/
https://ncbi.nlm.nih.gov/pubmed/31969805
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fncel.2019.00568
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