Orexin-A aggravates cytotoxicity and mitochondrial impairment in SH-SY5Y cells transfected with APPswe via p38 MAPK pathway

BACKGROUND: Alzheimer’s disease (AD) is one of the common neurodegenerative diseases and is characterized by the accumulation of amyloid-β (Aβ). Orexin-A is a neuropeptide produced in the hypothalamus and thought to be involved in the pathogenesis of AD. However, its underlying mechanism and signali...

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Detalhes bibliográficos
Publicado no:Ann Transl Med
Main Authors: Li, Maoyu, Meng, Yao, Chu, Bingcong, Shen, Yang, Liu, Xiangtian, Ding, Mao, Song, Chaoyuan, Cao, Xi, Wang, Ping, Xu, Linlin, Wang, Yun, Xu, Shunliang, Bi, Jianzhong, Xie, Zhaohong
Formato: Artigo
Idioma:Inglês
Publicado em: AME Publishing Company 2020
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6995740/
https://ncbi.nlm.nih.gov/pubmed/32055596
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.21037/atm.2019.11.68
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