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Site-directed targeting of transcriptional activation-associated proteins to repressed chromatin restores CRISPR activity

Previously, we used an inducible, transgenic polycomb chromatin system to demonstrate that closed, transcriptionally silenced chromatin reduces Cas9 editing. Here, we investigated strategies to enhance Cas9 editing efficiency by artificially perturbing closed chromatin. We tested UNC1999, a small mo...

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Detalles Bibliográficos
Publicado en:APL Bioeng
Main Authors: Daer, René, Hamna, Fatima, Barrett, Cassandra M., Haynes, Karmella A.
Formato: Artigo
Idioma:Inglês
Publicado: AIP Publishing LLC 2020
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6960031/
https://ncbi.nlm.nih.gov/pubmed/31967103
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1063/1.5127302
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