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Site-directed targeting of transcriptional activation-associated proteins to repressed chromatin restores CRISPR activity

Previously, we used an inducible, transgenic polycomb chromatin system to demonstrate that closed, transcriptionally silenced chromatin reduces Cas9 editing. Here, we investigated strategies to enhance Cas9 editing efficiency by artificially perturbing closed chromatin. We tested UNC1999, a small mo...

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Enregistré dans:
Détails bibliographiques
Publié dans:APL Bioeng
Auteurs principaux: Daer, René, Hamna, Fatima, Barrett, Cassandra M., Haynes, Karmella A.
Format: Artigo
Langue:Inglês
Publié: AIP Publishing LLC 2020
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6960031/
https://ncbi.nlm.nih.gov/pubmed/31967103
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1063/1.5127302
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