Metabolic engineering of Escherichia coli to produce a monophosphoryl lipid A adjuvant

Monophosphoryl lipid A (MPLA) species, including MPL (a trade name of GlaxoSmithKline) and GLA (a trade name of Immune Design, a subsidiary of Merck), are widely used as an adjuvant in vaccines, allergy drugs, and immunotherapy to boost the immune response. Even though MPLA is a derivative of lipopo...

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Bibliographic Details
Published in:Metab Eng
Main Authors: Ji, Yuhyun, An, Jinsu, Hwang, Dohyeon, Ha, Da Hui, Lim, Sang Min, Lee, Chankyu, Zhao, Jinshi, Song, Hyun Kyu, Yang, Eun Gyeong, Zhou, Pei, Chung, Hak Suk
Format: Artigo
Language:Inglês
Published: 2019
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6960009/
https://ncbi.nlm.nih.gov/pubmed/31786244
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ymben.2019.11.009
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