2-(3-Fluoro-4-methylsulfonylaminophenyl)propanamides as potent TRPV1 antagonists: Structure activity relationships of the 2-oxy pyridine C-region

The structure activity relationships of 2-oxy pyridine derivatives in the C-region of N-(6-trifluoromethyl- pyridin-3-ylmethyl) 2-(3-fluoro-4-methylsulfonylaminophenyl)propanamides as hTRPVl antagonists were investigated. The analysis indicated that the lipophilicity of the 2-oxy substituents was cr...

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Pubblicato in:Eur J Med Chem
Autori principali: Thorat, Shivaji A., Kang, Dong Wook, Ryu, HyungChul, Kim, Myeong Seop, Kim, Ho Shin, Ann, Jihyae, Ha, Taehwan, Kim, Sung-Eun, Son, Karam, Choi, Sun, Blumberg, Peter M., Frank, Robert, Bahrenberg, Gregor, Schiene, Klaus, Christoph, Thomas, Lee, Jeewoo
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2013
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6959545/
https://ncbi.nlm.nih.gov/pubmed/23685943
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejmech.2013.04.003
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