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Inhibition of FGFR Signaling Partially Rescues Osteoarthritis in Mice Overexpressing High Molecular Weight FGF2 Isoforms

Fibroblast growth factor 2 (FGF2) and fibroblast growth factor receptors (FGFRs) are key regulatory factors in osteoarthritis (OA). HMWTg mice overexpress the high molecular weight FGF2 isoforms (HMWFGF2) in osteoblast lineage and phenocopy both Hyp mice (which overexpress the HMWFGF2 isoforms in os...

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Foilsithe in:Endocrinology
Main Authors: Xiao, Liping, Williams, Donyell, Hurley, Marja M
Formáid: Artigo
Teanga:Inglês
Foilsithe: Oxford University Press 2020
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6959088/
https://ncbi.nlm.nih.gov/pubmed/31901095
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/endocr/bqz016
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