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Inhibition of FGFR Signaling Partially Rescues Osteoarthritis in Mice Overexpressing High Molecular Weight FGF2 Isoforms

Fibroblast growth factor 2 (FGF2) and fibroblast growth factor receptors (FGFRs) are key regulatory factors in osteoarthritis (OA). HMWTg mice overexpress the high molecular weight FGF2 isoforms (HMWFGF2) in osteoblast lineage and phenocopy both Hyp mice (which overexpress the HMWFGF2 isoforms in os...

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Pubblicato in:Endocrinology
Autori principali: Xiao, Liping, Williams, Donyell, Hurley, Marja M
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2020
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6959088/
https://ncbi.nlm.nih.gov/pubmed/31901095
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/endocr/bqz016
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